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Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape
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Analysis of Genes Associated With Monogenic Primary Immunodeficiency Identifies Rare Variants in XIAP in Patients With Crohn's Disease.
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Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape
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Tumor cells may circulate in medullary thyroid cancer patients independently of serum calcitonin
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
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Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis
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Dynamic Remodeling of membrane composition drives cell cycle through primary cilia excision
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The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating ERM proteins activation
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INPP5E Preserves Genomic Stability through Regulation of Mitosis
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New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity
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Structural Characterization, Technological Functionality and Physiological Aspects of Fungal β-D-Glucans : A Review
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Insight into SUCNR1 (GPR91) structure and function
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Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA
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From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
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Sphingolipids: Promising lipid-class molecules with potential applications for industry. A review
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Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models
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Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
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APOBEC3 Interference during Replication of Viral Genomes
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A fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae
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Prospective validation obtained in a similar group of patients and with similar high throughput biological tests failed to confirm signatures for prediction of response to chemotherapy and survival in advanced NSCLC: a prospective study from the European Lung Cancer Working Party
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Epigenetic modulators mitigate angiogenesis through a complex transcriptomic network
Shiva Shankar, T.V.; Willems, Luc
2014 • In Vascular Pharmacology, 60, p. 57-66
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The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription
Barez, Pierre-Yves ; Carpentier, Alexandre ; Boxus, Mathieu et al.
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Article (Scientific journals)
Hox protein interactions: screening and network building.
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An interaction map for HTLV-1 Tax and PDZ-containing proteins
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2014 • In Retrovirology, 11, p. 101
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Checkpoints modulation by the Human T-lymphotropic virus type 1 Tax protein
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2014 • In Retrovirology, 11 (S1), p. 90
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Hyper-replicative bovine leukemia virus by mutation of an envelope N-linked glycosylation site
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2014 • In Retrovirology, 11 (1), p. 141
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Elong Edimo, W; Schurmans, Stéphane ; Roger, PP et al.
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Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.
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2014 • In Viruses, 6 (6), p. 2416-2427
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Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia.
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2014 • In Molecular Biology of the Cell
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An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics.
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2014 • In Phytochemical Analysis, 25, p. 342-349
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Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet
Molina Ortiz, Patricia ; Polizzi, Séléna; Ramery, Eve et al.
2014 • In PLoS Genetics, 10 (6), p. 1004420
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DNA Damage and Thyroid Cancer
Neelature Sriramareddy, Sathyanarayana ; Staumont, Bernard ; Willems, Luc
2014 • In GIGADay-2014
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Generation and validation of a mouse model for conditional inactivation of PLAGL1
Pirottin, Dimitri ; Schurmans, Stéphane ; Francois, Cédric et al.
2014 • In Proceedings of the 4th edition : FARAH Day 2014
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A proteome-scale map of the human interactome network.
Rolland, Thomas; Tasan, Murat; Charloteaux, Benoît et al.
2014 • In Cell, 159 (5), p. 1212-26
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Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.
Shochat, Chen; Tal, Noa; Gryshkova, Vitalina et al.
2014 • In Blood, 124 (1), p. 106-10
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Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology
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2014 • In Brain: a Journal of Neurology, 137, p. 537-52
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The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2
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2013 • In PLoS ONE, 8 (9), p. 75102
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A new role for histone deacetylase 5 in the maintenance of long telomeres.
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2013 • In FASEB Journal, 27
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Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model
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2013 • In Retrovirology, 2013 (10), p. 75
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Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists
2013 • In European Journal of Medicinal Chemistry, 65, p. 32-40
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Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline ; Nasir, Mehmet Nail ; Nott, Katherine et al.
2013 • In World Academy of Science, Engineering and Technology, 77, p. 840
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Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline ; Nasir, Mehmet Nail ; Nott, Katherine et al.
2013 • In World Academy of Science, Engineering and Technology, 77, p. 840
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An eYFP Reporter Gene for the Yeast Two-hybrid System
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2013 • In Protein Journal, 32 (2), p. 126-130
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The role of TGFalpha in the resistance to mesothelioma chemotherapy
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2013 • In GIGA-Day 2013
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Identification of microRNA-based signatures for response and survival for non-small cell lung cancer treated with cisplatin-vinorelbine A ELCWP prospective study
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2013 • In Lung Cancer, 82, p. 340-345
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The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1.
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2013 • In PLoS ONE, 8 (11), p. 80387
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Direct and indirect use of GFP whole cell biosensors for the assessment of bioprocess performances: design of milliliter scale-down bioreactors
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2013 • In Biotechnology Progress, 29 (1), p. 48-59
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Thyroid-specific inactivation of Kif3a alters TSH signaling pathway and leads to hypothyroidism.
D'Amico, Eva; Gayral, Stéphanie; Massart, Claude et al.
2013 • In Journal of Molecular Endocrinology, 50, p. 375-387
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Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection
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2013 • In PLoS Pathogens, 9 (10)
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Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4
Hanson, Julien ; Ferreiros, Nerea; Pirotte, Bernard et al.
2013 • In Biochemical Pharmacology, 85, p. 1795-1802
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PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Martin, Maud ; Geudens, Ilse; Bruyr, Jonathan et al.
2013 • In EMBO Journal
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Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells
Pouillon, Valérie; Maréchal, Yoann; Frippiat, Christophe et al.
2013 • In Advances in Biological Regulation, 53 (1), p. 39-50
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The role of epigenetics in malignant pleural mesothelioma
Vandermeers, Fabian; Neelature Sriramareddy, Sathyanarayana ; Chrisostome, Costa et al.
2013 • In Lung Cancer, 81, p. 311-318
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WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?
Gillet, Nicolas ; Carpentier, Alexandre ; Barez, Pierre-Yves et al.
2012 • In Retrovirology, 9 (1), p. 115
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Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors
Gillet, Nicolas ; Vandermeers, Fabian ; De Brogniez, Alix et al.
2012 • In Pathogens, (2012-1), p. 65-82
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Interactomic map of the Ets factors family : Identification of unexpected functions in mRNA processing
Rambout, Xavier ; Simonis, Nicolas; Demoitié, Pauline et al.
2012 • In Keystone symposium - Protein-RNA Interactions in Biology and Disease (C1)
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Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
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2012 • In Blood, 119, p. 151-160
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How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells
Boxus, Mathieu ; Willems, Luc
2012 • In Retrovirology, 9 (2)
Paper published in a journal (Scientific congresses and symposiums)
Potentiality of using microbial biosensors for the detection of substrate heterogeneities and the assessment of microbial viability in industrial bioreactors: a complete set of experiments in chemostat and scale-down reactors, and elaboration of a mini scale-down platform
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2012 • In Communications in Agricultural and Applied Biological Sciences, 77 (1), p. 3-7
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The Spinner-IBMM mouse is a new spontaneous mutant in the Tmie gene
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2012 • In Genes and Genomics, 34, p. 107-110
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Interaction network of antimicrobial peptides of Arabidopsis thaliana, based on hith-throughput yeast two-hybrid screening
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2012 • In Plant Physiology and Biochemistry, p. 245-252
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Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse
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2012 • In Cellular Signalling, 24, p. 1971-1980
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Viral expression directs the fate of B cells in BLV-infected sheep.
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2012 • In Journal of Virology, 86 (1), p. 621-624
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Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin
Hanson, Julien ; Gille, Andreas; Offermanns, Stefan
2012 • In Pharmacology and Therapeutics
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Proinflammatory Cytokines Induce Bronchial Hyperplasia and Squamous Metaplasia in Smokers: Implications for chronic obstructive pulmonary disease therapy.
Herfs, Michael ; Hubert, Pascale ; POIRRIER, Anne-Lise et al.
2012 • In American Journal of Respiratory Cell and Molecular Biology, 47 (1), p. 67-79
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Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
Kasler, Herbert G.; Lim, Hyung W.; Mottet, Denis et al.
2012 • In EMBO Journal
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2012 • In BMC Developmental Biology, 12, p. 29
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The c-jun N-terminal Kinase (JNK)-binding Protein (JNKBP1) Acts as a Negative Regulator of NOD2 Protein Signaling by Inhibiting Its Oligomerization Process
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2012 • In Journal of Biological Chemistry, 287 (35), p. 29213-26
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HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells
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2012 • In Cell Death and Differentiation
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Phosphorylation of p65(RelA) on Ser547 by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stress.
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2012 • In PLoS ONE
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Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
Simonis, Nicolas; Rual, Jean-Francois; Lemmens, Irma et al.
2012 • In Retrovirology, 9, p. 26
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The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells.
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2012 • In Angiogenesis
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Transformation by deltaretroviruses: mechanisms and therapies
Willems, Luc
2012 • In Proceedings of the Belgian Royal Academies of Medicine, 1, p. 157-165
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Safety of long-term treatment of HAM/TSP patients with valproic acid
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2011 • In Blood, 118 (24), p. 6306-6309
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Importance of the PIKKs in NF-kappaB activation by genotoxic stress
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2011 • In Biochemical Pharmacology, 82 (10), p. 1371-83
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Opposite effects of valproate on Tax and HBZ expressions in T-lymphocytes from HTLV-1 asymptomatic carriers and HAM/TSP patients.
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2011 • In Blood, 118 (9), p. 2483-2491
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Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV
Rodriguez, Sabrina ; Florins, Arnaud-Francois ; Gillet, Nicolas et al.
2011 • In Viruses, 3 (7), p. 1210-1248
Paper published in a book (Scientific congresses and symposiums)
BM-573 INHIBITS THE EARLY ATHEROSCLEROTIC LESIONS IN APO-E DEFICIENT MICE BY BLOCKING TP RECEPTORS AND THROMBOXANE SYNTHASE
Cherdon, Céline ; Rolin, Stéphanie; Hanson, Julien et al.
2011 • In Congress of the International Society of Thrombosis and Hemostasis- 57th Annual SSC Meeting
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Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes.
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2011 • In Journal of Immunology, 186 (8), p. 4782-93
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BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase.
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2011 • In Prostaglandins and Other Lipid Mediators
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NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy.
Coupienne, Isabelle ; Bontems, Sébastien ; Dewaele, M. et al.
2011 • In Biochemical Pharmacology
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The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.
Vandevenne, Patricia ; Lebrun, Marielle ; El Mjiyad, Nadia et al.
2011 • In PLoS ONE, 9 (2)
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Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.
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2011 • In Cellular Microbiology, 13 (7), p. 1044-58
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Green fluorescent protein (GFP) leakage from microbial biosensors provides useful information for the evaluation of the scale-down effect
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2011 • In Biotechnology Journal, 6, p. 968-978
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The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6.
Legros, S.; Boxus, Mathieu ; GATOT, Jean-Stéphane et al.
2011 • In Oncogene
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Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials
lukasova, Martina; Hanson, Julien ; Tunaru, Sorin et al.
2011 • In Trends in Pharmacological Sciences
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Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells
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Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
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2011 • In Diabetes, 60, p. 2076-2085
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The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.
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Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.
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Valproate–doxorubicin: promising therapy for progressing mesothelioma. A phase II study
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2011 • In European Respiratory Journal, 37, p. 129-135
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Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb)
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2011 • In Advances in Enzyme Regulation, 51, p. 66-73
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Histone deacetylases: anti-angiogenic targets in cancer therapy.
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2010 • In Current Cancer Drug Targets, 10 (8), p. 898-913
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In vivo ribosomal RNA turnover is down-regulated in leukaemic cells in chronic lymphocytic leukaemia
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2010 • In British Journal of Haematology, 151
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DNA cytosine methylation in the Bovine Leukemia Virus promoter is associated with latency in a lymphoma-derived B-cell line potential involvement of direct inhibition of cAMP-responsive element (cre)-binding protein/cre modulator/activation transcription factor binding
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Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy
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2010 • In European Journal of Cancer, 46, p. 1724-1734
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Facilitating studies of cell proliferation in chronic lymphocytic leukemia
2010 • In Inserm Workshop: Interactomics: at the crossroads of biology and bioinformatics
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An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.
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2010 • In Cell Metabolism, 11 (4), p. 311-9
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Variegation and silencing in a lentiviral-based murine transgenic model.
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2010 • In Transgenic Research, 19, p. 399-414
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Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
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Long-term treatment with valproic acid does not alleviate the condition of HAM/TSP
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2009 • In AIDS Research and Human Retroviruses, 25 (11), p. 21
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Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis
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Developmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage.
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2009 • In Genesis, 47, p. 799-804
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Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies
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Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells.
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2009 • In British Journal of Haematology, 144 (1), p. 41-52
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Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads.
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Mechanisms of HTLV-1 persistence and transformation.
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2009 • In British Journal of Cancer, 101 (9), p. 1497-501
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Neuronal injury in NCX3 knockout mice following permanent focal cerebral ischemia and in NCX3 knockout cortical neuronal cultures following oxygen-glucose deprivation and glutamate exposure
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2009 • In Journal of Experimental Stroke and Translational Medicine, 2 (1), p. 3-9
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Reduced expression of cell cycle-associated genes in B lymphocytes purified from the peripheral blood of early-stage B chronic lymphocytic leukaemia (B-CLL) patients - response to di Iasio et al.
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2009 • In British Journal of Haematology
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Measurement of ribosomal RNA turnover in vivo by use of deuterium-labeled glucose.
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2009 • In Clinical Chemistry, 55 (10), p. 1824-33
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Earlier onset of delta-retrovirus-induced leukemia after splenectomy.
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2009 • In PLoS ONE, 4 (9), p. 6943
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INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
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2009 • In Nature Genetics, 41, p. 1027-1031
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Protein-protein interactions and gene expression regulation in HTLV-1 infected cells.
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Gene activation therapy: from the BLV model to HAM/TSP patients.
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HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
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A Dose-Effect Relationship For Deltaretrovirus-Dependent Leukemogenesis In Sheep
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Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma.
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2009 • In Clinical Cancer Research, 15 (8), p. 2818-28
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The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1-4, 2009; Salvador, Brazil).
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2009 • In Retrovirology, 6, p. 77
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Protein Phosphatase 2a Controls The Activity Of Histone Deacetylase 7 During T Cell Apoptosis And Angiogenesis
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How HTLV-1 may subvert miRNAs for persistence and transformation.
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Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.
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NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia
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Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
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Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate
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Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage
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Les histones desacetylases : nouvelles cibles pour les therapies anti-cancereuses.
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Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene.
Samuel, Shaija; Twizere, Jean-Claude ; Beifuss, Katherine K et al.
2008 • In Molecular Carcinogenesis, 47 (1), p. 34-46
Article (Scientific journals)
Implication des modifications épigénétiques dans les cancers : développement de nouvelles approches thérapeutiques
Vandermeers, Fabian ; Kettmann, Richard ; Willems, Luc
2008 • In Biotechnologie, Agronomie, Société et Environnement, 12 (2)
Article (Scientific journals)
Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents
Mineur, Pierre ; Colige, Alain ; Deroanne, Christophe et al.
2007 • In Journal of Cell Biology, 179 (6), p. 1261-1273
Article (Scientific journals)
Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis
Mottet, Denis ; Bellahcene, Akeila ; Pirotte, Sophie et al.
2007 • In Circulation Research, 101 (12), p. 1237-1246
Article (Scientific journals)
Histone Deacetylases: Target Enzymes for Cancer Therapy
Mottet, Denis ; Castronovo, Vincenzo
2007 • In Clinical and Experimental Metastasis
Article (Scientific journals)
Phosphoinositide phosphatases in a network of signaling reactions
Blero, D.; Payrastre, B.; Schurmans, Stéphane et al.
2007 • In Pflügers Archiv: European Journal of Physiology, 455, p. 31-44
Article (Scientific journals)
Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses
Burteau, C.; Willems, Luc ; Kettmann, Richard
2007 • In Biotechnologie, Agronomie, Société et Environnement
Paper published in a journal (Scientific congresses and symposiums)
BM-573, a thromboxane receptor antagonist, reduces development of atherosclerosis in apoE–deficient mice
Cherdon, Céline ; Rolin, Stéphanie; Hanson, Julien et al.
2007 • In Journal of Molecular and Cellular Cardiology, 42 (suppl 1.), p. 33-34
Article (Scientific journals)
Cell dynamics and immune response to BLV infection: a unifying model
Florins, Arnaud-Francois ; Gillet, Nicolas ; Asquith, Becca et al.
2007 • In Frontiers in Bioscience: A Journal and Virtual Library, 12, p. 1520-1531
Article (Scientific journals)
Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep.
Florins, Arnaud-Francois ; Gillet, Nicolas ; Boxus, Mathieu et al.
2007 • In Journal of Virology, 81 (18), p. 10195-200
; Sayyed, Sufyan Ali 
